ABSTRACT
The relation between Helicobacter pylori (Hp) eradication and prevention of stomach carcinoid development has hitherto remained unclear. We therefore examined this problem using an Hp-infected and Hp-eradicated Mongolian gerbil (MG) model. Enterochromaffin-like (ECL) lesions (hyperplasia/dysplasia and carcinoid) were histopathologically evaluated in the glandular stomachs of Hp-infected and Hp-eradicated MGs. In addition, serum gastrin levels were analyzed. Hp infection induced significant increase in the development of ECL lesions in the glandular stomach, as well as serum gastrin levels as compared with non-infected MGs, while Hp eradication was associated with significant alleviation. The development of ECL lesions in the glandular stomach strongly correlated with titers of anti-Hp antibodies and serum gastrin levels in MGs. In conclusion, Hp infection induces carcinoid development, and Hp eradication prevents its occurrence in the glandular MG stomach, this being strongly linked with reduction in serum gastrin levels.
Subject(s)
Animals , Anti-Bacterial Agents/pharmacology , Carcinoid Tumor/etiology , Enterochromaffin-like Cells/pathology , Gastrins/blood , Gerbillinae , Helicobacter Infections/complications , Helicobacter pylori/drug effects , Hyperplasia , Male , Stomach Neoplasms/etiologyABSTRACT
BACKGROUND/AIMS: Carcinoid tumors are submucosal tumors with metastatic potential. We tried to determine the clinical course of gastrointestinal (GI) carcinoid tumors and find the factors predicting metastasis. METHODS: We reviewed the clinical records of 81 cases with GI carcinoid tumors. Involved organ, age, sex, symptoms, treatments, and metastatic patterns were reviewed. We evaluated the macroscopic and microscopic parameters to predict the metastatic potential of GI carcinoid tumors. RESULTS: The common sites of GI carcinoids were rectum (71.7%), stomach (13.6%), and duodenum (8.6%). Mean age of the patients was 49 years old with a peak incidence of sixth decade. Male to female ratio was 1.38:1. Most symptoms were usually nonspecific. Fifty five patients (67.9%) received endoscopic treatments while 23 patients (28.4%) received surgical treatment. Patients were followed up for a mean period of 15.6 months. There were 10 cases (12.3%) of metastasis. There were significantly more metastasis in patients with tumor size >10 mm (p2, or Ki-67 labeling index >2 in microscopic parameter (p10 mm, central depression or ulcer, invasion below submucosa, lymphatic or venous invasion, mitosis >2, and Ki-67 labeling index >2 have higher metastatic potential. Those with risk factors predicting metastasis should be treated and followed carefully.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoid Tumor/etiology , Disease Progression , Gastrointestinal Neoplasms/etiology , Neoplasm Invasiveness , Neoplasm Metastasis , Predictive Value of Tests , Retrospective StudiesABSTRACT
No abstract available.
Subject(s)
Humans , Carcinoid Tumor/etiology , Disease Progression , Gastrointestinal Neoplasms/etiology , Ki-67 Antigen/analysis , Neoplasm Metastasis , Predictive Value of TestsABSTRACT
No abstract available.
Subject(s)
Humans , Male , Middle Aged , Carcinoid Tumor/etiology , Colonoscopy , Lymphatic Metastasis , Muscles/pathology , Neoplasm Invasiveness , Rectal Neoplasms/etiologyABSTRACT
Primary carcinoid tumours of the presacral region are extremely infrequent with just a handful of such cases reported in literature. Tailgut cysts(retrorectal cystic hamartoma) are also very uncommon lesions which are usually identified in adult life. They are developmental abnormalities and consist of multiloculated cysts lined by squamous, transitional or glandular epithelium. Malignant transformation within tailgut cysts is rare; the tumours which arise include carcinoid tumours and adenocarcinomas. We report the unusual occurrence of a carcinoid tumour developing within a tailgut cyst.
Subject(s)
Adult , Carcinoid Tumor/etiology , Female , Hamartoma/complications , Humans , Sacrococcygeal RegionABSTRACT
Los tumores carcinoides son neoplasias raras originales en células neuroendocrinas. La gran mayoria (85 por ciento) se originan en el apéndice cecal, siendo la ubicación gástrica de baja frecuencia. Desde el punto de vista clínico-patológico se ha dividido a los tumores carcinoides gástrico en tres tipos: tumor enterocromafín-like (ECL) asociado a gastritis crónica atrófica tipo A, tumor carcinoide ECL asociado a Zollinger-Ellison/ MEN-I, y tumor argirófilo esporádico, los cuales varían en su etiopatogenia y forma de evolución. Se presenta el caso de un tumor argirófilo esporádico, entidad extremadamente rara y con escasos reporte de literatura
Subject(s)
Humans , Male , Middle Aged , Carcinoid Tumor/diagnosis , Stomach Neoplasms/diagnosis , Carcinoid Tumor/etiology , Carcinoid Tumor/surgery , Gastrectomy , Immunohistochemistry , Neuroendocrine Tumors/diagnosis , Stomach Neoplasms/etiology , Stomach Neoplasms/surgeryABSTRACT
Se presenta el caso de una paciente de 52 años quien venía presentando desde hace 5 años crisis de broncoespasmo, rubor facial, palpitaciones y episodios de diarrea. Por un cuadro de obstrucción intestinal es llevada a cirugía, encontrandose una tumoración en el ileon distal que histológicamente correspondio a un tumor carcinoide. El objeto de la presente publicación es insistir en la importancia que tiene esta entidad